The variation of the novel allele HLA-B*0739 suggests low alloreactivity when mismatched with HLA-B*0702.

Abstract

We here report the identification of a new HLA-B*07 allele in a male Caucasian. The new allele was initially typed as B*0713 by sequence-specific primed PCR. Because of the infrequence of that allele, a sequencing-based typing was performed to confirm that result. This yielded the detection of the novel allele. It is closest to B*070201, while it differs from B*0713 in 12 positions in exon 2. Compared to B*070201, the new variant is characterized by a non-synonymous nucleotide exchange (C-->T) at nucleotide position 118 of exon 2. Previously, this was considered a constant position, suggesting that it is likely to be caused by a single-point mutation. It results in the amino acid exchange Ala-->Val at position 40 of the mature polypeptide. As this position is located in an outer loop of the HLA molecule, it is highly unlikely to affect peptide binding or T-cell receptor interaction. Thus, the newly found allele should have a low alloreactive potential in case of a mismatch to the most common HLA-B allele B*0702.

Cite this paper

@article{Horn2005TheVO, title={The variation of the novel allele HLA-B*0739 suggests low alloreactivity when mismatched with HLA-B*0702.}, author={Peter A. Horn and Rainer Blasczyk}, journal={Tissue antigens}, year={2005}, volume={66 1}, pages={56-7} }