The variation in strength of the human blood group P

  title={The variation in strength of the human blood group P},
  author={Ronald Aylmer Sir Fisher},
  • R. Fisher
  • Published 1 April 1953
  • Medicine
  • Heredity
SOON after their discovery (i) of the blood group known by the genetical symbols F, p, Landsteiner and Levine called attention to the great variability of the P reaction with anti-P sera. This variability has proved very troublesome, and for some years the validity of estimates of gene frequencies was in some doubt, owing to the possibility that an unknown proportion of weak positive reactions were passing as negative. Moreover, there is still no anti-p reagent to supplement the typing antibody… 
Studies on the genetic basis of Pk, P and P1 blood group antigen expression
No clear-cut correlation was found and two previously proposed P2-specific mutations were detected in homozygous form both in P1 and P2 donors indicating that these mutations are not the sole cause of the P1/P2 status.
Some Notes on Fisher’s Contributions to Human Blood Groups
By 1941 it was realized that the Rh groups were not as simple as they had first appeared, and in the two following years a system of what then seemed bewildering complexity unfolded itself. By the
A rare blood group antigen, R1a (Rosenlund).
  • L. Kornstad
  • Medicine, Biology
    Immunological communications
  • 1980
Independent segregation was demonstrated between Rla and the ABO, MNSs, Rh, Lutheran, Duffy and Kidd blood group systems, the ABH secretor genes, and sex.
P1PK: a blood group system with an identity crisis
Step by step, the biochemical and genetic basis underlying the antigens expressed in this system has been revealed, answering some of the questions such as why individuals with p phenotype lack not only Pk and P expression, but also P1, and whether the P1 antIGens exist on both glycolipids and glycoproteins on the human red blood cells.
Association between HLA and Red Cell Antigens
The conclusion is that several factors are likely to be responsible for the great variation in HLA reactivity of RBC.
Identification of a novel A4GALT exon reveals the genetic basis of the P1/P2 histo-blood groups.
P(1) zygosity partially explains the well-known interindividual variation in P1 strength and future investigations need to focus on regulatory mechanisms underlying P1 synthesis.
Studies of human alloantigens on man‐mouse hybrids: possible syntheny between hl‐a and p systems
Preliminary experiments were made using antibody‐induced redistribution phenomena (capping) to study the relationships between P and HL‐A antigens at the cell surface and indicated that the two molecules are independent of one another.
Variations of H, A and B Antigen Strengths among Melanesians
Although the average H content of Melanesian and Caucasian samples did not differ significantly, 10% of O and over 20% of A1 and B bloods from coastal Austronesian speakers had higher H than was found among Caucasians.
Genetic Markers in Human Blood
The genetics and distribution of some of the polymorphic traits - blood groups, human leucocyte antigens, serum proteins, red cell enzymes, haemoglobins and DNA are reviewed.
Association between HL‐A and Red Cell Antigens
AutoAnalyzer analyses were performed in two series of cytotoxic HL‐A antisera in the anti‐HL‐A7/W27 cross‐reacting group, and the results showed HL-A7‐related haemagglutinins in nearly all the sera inthe first group, while in the second group only two haemAGglutinating sera were found, and they did not show any obvious HL‐ A association.


Further Observations on Individual Differences of Human Blood.
With a method similar to that employed for the detection of M, namely, suitable absorption of certain rabbit immune sera for human blood, two other agglutinable qualities were found which may be denoted as N and P.
Investigations on the blood factor P
  • Acta Path . Scand .
  • 1949
Further observations on individual
  • 1927