• DOI:10.1038/hdy.1953.7
• Corpus ID: 391794

The variation in strength of the human blood group P

@article{Fisher1953TheVI,
  title={The variation in strength of the human blood group P},
  author={Ronald Aylmer Sir Fisher},
  journal={Heredity},
  year={1953},
  volume={7},
  pages={81-90}
}

• R. Fisher
• Published 1 April 1953
• Medicine
• Heredity

SOON after their discovery (i) of the blood group known by the genetical symbols F, p, Landsteiner and Levine called attention to the great variability of the P reaction with anti-P sera. This variability has proved very troublesome, and for some years the validity of estimates of gene frequencies was in some doubt, owing to the possibility that an unknown proportion of weak positive reactions were passing as negative. Moreover, there is still no anti-p reagent to supplement the typing antibody first discovered. Owing to the improved technique developed by Jonsson and Henningsen (2), and the use of potent testing fluids, the difficulty of distinguishing weakly reacting blood containing P from the recessive form pp is now believed to be overcome. The causes of variation in strength are, however, still obscure. Henningsen has indeed suggested (3) that his data may be interpreted as showing a series of four alleles p . . . . . 47 per cent. Pweak . . . 10 P medium . 40 ,, P strong . 3