The variant form of hairy-cell leukaemia.

  title={The variant form of hairy-cell leukaemia.},
  author={Estella Matutes and Andrew Charles Wotherspoon and Daniel Catovsky},
  journal={Best practice & research. Clinical haematology},
  volume={16 1},
Hairy-cell leukaemia-variant (HCL-variant) is a rare B-cell disorder which accounts for 10% of HCL cases. It affects elderly or middle-aged males. The main features are splenomegaly, lymphocytosis and cytopenias without monocytopenia. The circulating cells have a morphology intermediate between prolymphocytes and hairy cells. The immunophenotype shows a mature B-cell phenotype with expression of the B-cell antigens CD11c and CD103-but unlike typical HCL the cells are CD25- and HC2-negative. The… CONTINUE READING
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