The variable regions of hepatitis C virus glycoprotein E2 have an essential structural role in glycoprotein assembly and virion infectivity.

@article{McCaffrey2011TheVR,
  title={The variable regions of hepatitis C virus glycoprotein E2 have an essential structural role in glycoprotein assembly and virion infectivity.},
  author={Kathleen McCaffrey and Hamed Gouklani and Irene Boo and Pantelis Poumbourios and Heidi E Drummer},
  journal={The Journal of general virology},
  year={2011},
  volume={92 Pt 1},
  pages={112-21}
}
The three variable regions of hepatitis C virus (HCV) glycoprotein E2 can be removed simultaneously from the E2 ectodomain (residues 384-661) without affecting folding or CD81 binding. In this study, we show that deletion of hypervariable region (HVR) 2 or the intergenotypic variable region (igVR) in the context of the E1E2 polyprotein eliminates formation of heterodimers, reduces CD81 binding and abolishes virus entry. The replication competence of genomic RNA transcribed from the JFH1… CONTINUE READING
Highly Cited
This paper has 56 citations. REVIEW CITATIONS

Citations

Publications citing this paper.
Showing 1-10 of 24 extracted citations

56 Citations

01020'12'14'16'18
Citations per Year
Semantic Scholar estimates that this publication has 56 citations based on the available data.

See our FAQ for additional information.

References

Publications referenced by this paper.
Showing 1-10 of 44 references

Similar Papers

Loading similar papers…