The variable penetrance and spectrum of manifestations of multiple endocrine neoplasia type 1.

@article{Carty1998TheVP,
  title={The variable penetrance and spectrum of manifestations of multiple endocrine neoplasia type 1.},
  author={Sally E. Carty and Alison Helm and Janet A. Amico and M. R. B. Clarke and Thomas P. Foley and Clinic Watson and John J. Mulvihill},
  journal={Surgery},
  year={1998},
  volume={124 6},
  pages={1106-13; discussion 1113-4}
}
BACKGROUND Some experts maintain that (1) > 90% of patients with multiple endocrine neoplasia type 1 (MEN1) are first seen with hyperparathyroidism (HPTH) so that routine screening for other features is unnecessary and (2) MEN1 has > or = 94% penetrance by age 50 years. METHODS We constructed a regional registry of patients with or at risk for MEN1 and examined phenotypic profiles in 34 patients. MEN1 was defined as (1) endocrinopathy of 2 of the 3 principal related tissues (parathyroid… CONTINUE READING
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