The variable C-terminus of cysteine string proteins modulates exocytosis and protein-protein interactions.

@article{Boal2004TheVC,
  title={The variable C-terminus of cysteine string proteins modulates exocytosis and protein-protein interactions.},
  author={Fr{\'e}d{\'e}ric Boal and Hui Zhang and C{\'e}line Tessier and Pier A Scotti and Jochen Lang},
  journal={Biochemistry},
  year={2004},
  volume={43 51},
  pages={16212-23}
}
Cysteine string proteins (Csps) are vesicle proteins involved in neurotransmission and hormone exocytosis. They are composed of distinct domains: a variable N-terminus, a J-domain followed by a linker region, a cysteine-rich string, and a C-terminus which diverges among isoforms. Their precise function and interactions are not fully understood. Using insulin exocytosis as a model, we show that the linker region and the C-terminus, but not the variable N-terminus, regulate overall secretion… CONTINUE READING

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