The vanishing twin: an explanation for discordance between chorionic villus karyotype and fetal phenotype.

@article{Reddy1991TheVT,
  title={The vanishing twin: an explanation for discordance between chorionic villus karyotype and fetal phenotype.},
  author={K. Sreenivasulu Reddy and Michael Bjorn Petersen and Stylianos E. Antonarakis and Karin J. Blakemore},
  journal={Prenatal diagnosis},
  year={1991},
  volume={11 9},
  pages={679-84}
}
One 'erroneous' diagnosis occurred in 200 first-trimester chorionic villus samples (CVS) analysed. In direct preparations following 24 h incubation as well as in long-term cultures, a 46,XX karyotype was observed in the villi (28 and 25 cells, respectively). At 20 weeks of gestation, labour was induced because of fetal death in utero. An autopsy performed on the fetus revealed a male phenotype. Placenta and fetal tissues were not submitted for cytogenetic studies. The discordant CVS karyotype… CONTINUE READING