The vanilloid receptor: a molecular gateway to the pain pathway.

  title={The vanilloid receptor: a molecular gateway to the pain pathway.},
  author={Michael J. Caterina and David Julius},
  journal={Annual review of neuroscience},
The detection of painful stimuli occurs primarily at the peripheral terminals of specialized sensory neurons called nociceptors. These small-diameter neurons transduce signals of a chemical, mechanical, or thermal nature into action potentials and transmit this information to the central nervous system, ultimately eliciting a perception of pain or discomfort. Little is known about the proteins that detect noxious stimuli, especially those of a physical nature. Here we review recent advances in… 

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  • 2013
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Impaired nociception and pain sensation in mice lacking the capsaicin receptor.

Sensory neurons from mice lacking VR1 are severely deficient in their responses to each of these noxious stimuli and are impaired in the detection of painful heat, and showed little thermal hypersensitivity in the setting of inflammation.

Vanilloid receptor-1 is essential for inflammatory thermal hyperalgesia

It is concluded that VR1 is required for inflammatory sensitization to noxious thermal stimuli but also that alternative mechanisms are sufficient for normal sensation of noxious heat.

A capsaicin-receptor homologue with a high threshold for noxious heat

It is proposed that responses to noxious heat involve these related, but distinct, ion-channel subtypes that together detect a range of stimulus intensities.

A novel heat-activated current in nociceptive neurons and its sensitization by bradykinin.

  • P. CesareP. McNaughton
  • Biology
    Proceedings of the National Academy of Sciences of the United States of America
  • 1996
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Acid potentiation of the capsaicin receptor determined by a key extracellular site.

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