The vanilloid receptor: a molecular gateway to the pain pathway.

  title={The vanilloid receptor: a molecular gateway to the pain pathway.},
  author={Michael J. Caterina and David Julius},
  journal={Annual review of neuroscience},
The detection of painful stimuli occurs primarily at the peripheral terminals of specialized sensory neurons called nociceptors. These small-diameter neurons transduce signals of a chemical, mechanical, or thermal nature into action potentials and transmit this information to the central nervous system, ultimately eliciting a perception of pain or discomfort. Little is known about the proteins that detect noxious stimuli, especially those of a physical nature. Here we review recent advances in… CONTINUE READING
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