The value of the dental impaction pain model in drug development.

  title={The value of the dental impaction pain model in drug development.},
  author={Stephen A. Cooper and Paul J. Desjardins},
  journal={Methods in molecular biology},
The modern version of the Dental Impaction Pain Model (DIPM) was developed in the mid-1970s. Since that time, several hundred studies have been conducted by numerous investigators. Today it is arguably the most utilized of all the acute pain models. Its popularity is due to the success rate of the studies, fast subject entry, and cost effectiveness. The surgical procedure is extremely standardized, and the surgery requires either minimal or no use of CNS depressant anesthetics. The methodology… CONTINUE READING


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Multidose analgesic study of two mefanamic acid formulations in a postsurgical dental pain

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