The value of plants used in traditional medicine for drug discovery.
@article{Fabricant2001TheVO, title={The value of plants used in traditional medicine for drug discovery.}, author={Daniel S. Fabricant and N. R. Farnsworth}, journal={Environmental Health Perspectives}, year={2001}, volume={109}, pages={69 - 75} }
In this review we describe and discuss several approaches to selecting higher plants as candidates for drug development with the greatest possibility of success. We emphasize the role of information derived from various systems of traditional medicine (ethnomedicine) and its utility for drug discovery purposes. We have identified 122 compounds of defined structure, obtained from only 94 species of plants, that are used globally as drugs and demonstrate that 80% of these have had an ethnomedical…
2,102 Citations
Traditional medicines in drug discovery
- Medicine, Biology
- 2016
The review covered all aspects of traditional medicines and revealed that a detailed experimental as well as standardization study is required to explore the plants and their uses to treat serious complication.
The Ethnopharmacologic Contribution to Bioprospecting Natural Products.
- BiologyAnnual review of pharmacology and toxicology
- 2018
Although this ethnopharmacologic resource is threatened by the loss of traditional medicine knowledge and extinction of organisms, researchers can now rapidly analyze and identify the multiple, and often synergistic, compounds contained in these natural products.
Therapeutic potential of medicinal plants: A review
- Biology, Chemistry
- 2020
A number of medicinal plants have been subjected to detailed chemical investigations and this has led to the isolation of pure bioactive molecules which have been pharmacologically evaluated, and as a result, new drugs have been discovered, along with new applications.
Drug Discovery from Plants
- Biology, Chemistry
- 2008
In the future, plant-derived compounds will still be an essential aspect of the therapeutic array of medicines available to the physician, particularly with the availability of new hyphenated analytical methods such as LC-NMR-MS and LC-SPE-N MR to accelerate their future discovery.
Ethno–Phytopharmacology: Product Validation Process Based on Traditional Knowledge of Medicinal Plants
- Biology, Medicine
- 2020
Ethno-phytopharmacology studies the traditional use of plants for the prevention and cure of several diseases. It provides multidisciplinary research on components of medicinal plants, their…
Ethnopharmacology-A Novel Approach for Drug Discovery
- Biology
- 2015
Hurdles like lack of trials, safety and efficacy records, gap between old concepts and modern understanding, malpractice due to intense competition in drug research, carelessly carried out bioassays and biopiracy stop knowledge from becoming mainstream.
Screening of natural products for drug discovery
- BiologyExpert opinion on drug discovery
- 2007
The place of natural products in the therapeutic arsenal is rigorously analysed and several approaches in selecting and screening natural products as candidates for drug discovery and for drug development are described and discussed.
Traditional Medicines for Treatment African Diseases by Artemisia Annua
- Biology
- 2016
The purpose of this review is giving the information regarding the medicine plant in Ethiopia, the history, availability in Ethiopia and application has been discussed.
References
SHOWING 1-10 OF 118 REFERENCES
The role of ethnopharmacology in drug development.
- BiologyCiba Foundation symposium
- 1990
Examples are given to illustrate how data from ethnomedicine can be analysed with the aim of selecting a reasonable number of plants to be tested in bioassay systems that are believed to predict the action of these drugs in humans.
Medicinal plants in therapy.
- Political Science, MedicineBulletin of the World Health Organization
- 1985
From plant to patient: an ethnomedical approach to the identification of new drugs for the treatment of NIDDM
- MedicineDiabetologia
- 1997
The case is presented for an alternative pathway to discovery of drugs for the treatment of NIDDM; one based on an ethnomedical approach, involving ethnobotany and traditional medicine.
Can ethnopharmacology contribute to the development of antiviral drugs?
- BiologyJournal of ethnopharmacology
- 1991
Pharmacognosy in the New Millennium: Leadfinding and Biotechnology
- BiologyThe Journal of pharmacy and pharmacology
- 2000
The food-processing industry is heavily investing in this branch, which results in an improve of the overall quality of the authors' diet, including the development of functional food and neutraceuticals, based on growing awareness that a large number of secondary metabolites playing a significant role for the prevention of diseases are also present in food.
Ethnopharmacology and drug development.
- Medicine, BiologyCiba Foundation symposium
- 1994
This combination of analysing ethnomedical information and published scientific studies on plant extracts (ethnopharmacology) may reduce the number of plants that need to be screened for drug discovery attempts, resulting in a corresponding greater success rate than by random selection and mass bioscreening.
Cryptolepis sanguinolenta: an ethnobotanical approach to drug discovery and the isolation of a potentially useful new antihyperglycaemic agent
- BiologyDiabetic medicine : a journal of the British Diabetic Association
- 1998
Evidence that cryptolepine, an indoloquinolone alkaloid isolated from Cryptolepis sanguinolenta, significantly lowers glucose when given orally to a mouse model of diabetes is presented, allowing us to conclude that an ethnobotanical approach to drug discovery can identify a potentially usful drug for the treatment of Type 2 DM.
Problems and Prospects of Discovering New Drugs from Higher Plants by Pharmacological Screening
- Environmental Science
- 1977
There are probably very few in attendance at this Congress who have not experienced the frustrations of initiating research on plants alleged to have interesting biological activity, only to find…
Ethnobotany and drug discovery: the experience of the US National Cancer Institute.
- Environmental ScienceCiba Foundation symposium
- 1994
Results indicate that the current NCI collection policy offers the best chances for the discovery and development of agents for the treatment of AIDS (acquired immune deficiency syndrome) and cancer.