The value of detecting anti-VZV IgG antibody in CSF to diagnose VZV vasculopathy

@article{Nagel2007TheVO,
  title={The value of detecting anti-VZV IgG antibody in CSF to diagnose VZV vasculopathy},
  author={Maria A. Nagel and Bagher Forghani and Ravi Mahalingam and Mary C. Wellish and Randall J. Cohrs and Andrew N. Russman and Irene L. Katzan and Ru Lin and C J Gardner and Donald H. Gilden},
  journal={Neurology},
  year={2007},
  volume={68},
  pages={1069 - 1073}
}
Background: Factors that may obscure the diagnosis of varicella zoster virus (VZV) vasculopathy include the absence of rash before TIAs or stroke as well as similar clinical features and imaging, angiographic, and CSF abnormalities to those of other vasculopathies. Diagnosis relies on virologic confirmation that detects VZV DNA, anti-VZV IgG antibody, or both in the CSF. Methods: We reviewed our current 14 cases of patients diagnosed with VZV vasculopathy based on combined clinical, imaging… 
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199 Citations

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References

SHOWING 1-10 OF 22 REFERENCES
The value of cerebrospinal fluid antiviral antibody in the diagnosis of neurologic disease produced by varicella zoster virus
Multifocal vasculopathy due to Varicella-Zoster Virus (VZV): serial analysis of VZV DNA and intrathecal synthesis of VZV antibody in cerebrospinal fluid.
  • A. Kronenberg, R. Schupbach, +4 authors R. Speck
  • Medicine, Biology
    Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
  • 2002
TLDR
A human immunodeficiency virus-infected patient who had progressive central nervous system disease for >3 months was described, and serial polymerase chain reaction analyses confirmed the diagnosis and guided the duration of therapy.
Encephalitis related to primary varicella-zoster virus infection in immunocompetent children
Rapid diagnosis of herpes simplex encephalitis by nested polymerase chain reaction assay of cerebrospinal fluid
CSF and MRI findings in patients with acute herpes zoster
TLDR
Subclinical extension of viral inflammation into the CNS occurs commonly in HZ, and this finding may have implications for treatment of HZ and prevention of various associated complications.
Quantification of virus-specific antibodies in cerebrospinal fluid and serum: sensitive and specific detection of antibody synthesis in brain.
TLDR
The method has applied successfully to antibodies to measles, rubella, herpes simplex, varicella-zoster, human immunodeficiency virus, and cytomegalovirus, and to anti-Toxoplasma or -Borrelia antibodies.
Varicella zoster virus-associated focal vasculitis without herpes zoster: Recovery after treatment with acyclovir
TLDR
An immunocompetent patient without rash is treated, who developed a focal vasculitis of the proximal part of the middle cerebral artery most probably caused by the varicella zoster virus.
Herpes zoster ophthalmicus and delayed contralateral hemiparesis caused by cerebral angiitis: Diagnosis and management approaches
Four patients with herpes zoster ophthalmicus and delayed contralateral hemiparesis are described, and their findings are compared with those in patients previously reported in the English language…
[Granulomatous vasculitis of the CNS as a complication of herpes zoster ophthalmicus].
A 61-year old man with a history of arterial hypertension suffered a left HZO, and was treated with acyclovir. Three weeks later he suddenly developed moderate left hemiparesis particularly of the…
Multifocal varicella-zoster virus vasculopathy without rash.
TLDR
A 51-year-old woman with CREST syndrome developed stepwise progressive focal neurological deficits without zoster rash and treatment with intravenous acyclovir stabilized but did not significantly improve her neurological deficits.
...
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