The value of anti-pax-5 immunostaining in routinely fixed and paraffin-embedded sections: a novel pan pre-B and B-cell marker.

@article{Torlakovic2002TheVO,
  title={The value of anti-pax-5 immunostaining in routinely fixed and paraffin-embedded sections: a novel pan pre-B and B-cell marker.},
  author={Emina Emilia Torlakovic and Goran Torlakovic and Phuong Ngan Le Nguyen and Richard D. Brunning and Jan Delabie},
  journal={The American journal of surgical pathology},
  year={2002},
  volume={26 10},
  pages={
          1343-50
        }
}
Whereas L26 (anti-CD20) is well established as a B-cell marker of high specificity for use in paraffin-embedded tissues and JCB117 (anti-CD79a) is increasingly used, a comparable additional pan-B-cell antibody has hitherto not yet been identified. Here we have studied the use of a novel anti-pan-B-cell marker Pax-5 for use in diagnostic pathology. Pax-5 encodes for BSAP (Pax-5), a B-cell-specific transcription factor, the expression of which is detectable as early as the pro-B-cell stage and… CONTINUE READING
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