The value and limitation of iloprost infusion in decreasing skeletal muscle necrosis.

@article{Mohan1992TheVA,
  title={The value and limitation of iloprost infusion in decreasing skeletal muscle necrosis.},
  author={Chandrasekaran Victor Raj Mohan and Corrado Paolo Marini and Marta Gennaro and Elia Ascer},
  journal={Journal of vascular surgery},
  year={1992},
  volume={16 2},
  pages={
          268-73
        }
}
Iloprost has been shown to minimize skeletal muscle necrosis when administered before the onset of ischemia in animal experiments, possibly by preventing neutrophil activation. Since patients with acute limb ischemia are seen after the process has begun, we investigated whether iloprost can be protective when given only during reperfusion. After anesthesia, 18 adult mongrel dogs underwent a standard isolated gracilis muscle preparation. In six control animals (group I) the gracilis muscle was… CONTINUE READING

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