The valproic acid-induced rodent model of autism.

  title={The valproic acid-induced rodent model of autism.},
  author={Chiara Nicolini and Margaret Fahnestock},
  journal={Experimental neurology},
  volume={299 Pt A},
Autism is a lifelong neurodevelopmental disorder characterized by impairments in social communication and interaction and by repetitive patterns of behavior, interests and activities. While autism has a strong genetic component, environmental factors including toxins, pesticides, infection and drugs are known to confer autism susceptibility, likely by inducing epigenetic changes. In particular, exposure to valproic acid (VPA) during pregnancy has been demonstrated to increase the risk of autism… CONTINUE READING
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