The validation of a new high throughput method for determination of chloramphenicol in milk using liquid–liquid extraction with low temperature partitioning (LLE-LTP) and isotope-dilution liquid chromatography tandem mass spectrometry (ID-LC-MS/MS)

@article{Rego2015TheVO,
  title={The validation of a new high throughput method for determination of chloramphenicol in milk using liquid–liquid extraction with low temperature partitioning (LLE-LTP) and isotope-dilution liquid chromatography tandem mass spectrometry (ID-LC-MS/MS)},
  author={E. P. Rego and E. F. Guimar{\~a}es and Ana Luiza Monteiro dos Santos and E. Mothe and J. M. Rodrigues and A. D. P. Netto},
  journal={Analytical Methods},
  year={2015},
  volume={7},
  pages={4699-4707}
}
Chloramphenicol (CAP) is an antibiotic banned for treatment of food-producing animals. The minimum required performance limit (MRPL) of 0.3 μg kg−1 for analytical methods was set by the European Community for the detection of its residues in different matrices, including milk. A highly sensitive analytical method using isotope-dilution liquid chromatography tandem mass spectrometry (ID-LC-MS/MS) and liquid–liquid extraction with low temperature partitioning (LLE-LTP) was developed and validated… Expand
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