The validation of Calophyllum brasiliense (“guanandi”) uses in Brazilian traditional medicine as analgesic by in vivo antinociceptive evaluation and its chemical analysis

@article{KleinJnior2017TheVO,
  title={The validation of Calophyllum brasiliense (“guanandi”) uses in Brazilian traditional medicine as analgesic by in vivo antinociceptive evaluation and its chemical analysis},
  author={Luiz Carlos Klein-J{\'u}nior and Daniele Zambiasi and Giovana Rocha Salgado and Franco Delle Monache and Valdir Cechinel Filho and F{\'a}tima de Campos Buzzi},
  journal={Naunyn-Schmiedeberg's Archives of Pharmacology},
  year={2017},
  volume={390},
  pages={733-739}
}
Calophyllum brasiliense is used as anti-inflammatory and analgesic in Brazilian traditional medicine. Thus, the main purpose of this study is to evaluate the antinociceptive effect of the chloroform fraction of C. brasiliense (CFCB) roots and to investigate its main mechanism of action. The antinociceptive effect of CFCB was evaluated in mice using acetic acid-induced writhing, formalin-induced paw licking, and hot-plate tests and capsaicin- and glutamate-induced nociception. Brasiliensic acid… 
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