The vagina as a route for drug delivery: a review

@article{Srikrishna2012TheVA,
  title={The vagina as a route for drug delivery: a review},
  author={Sushma Srikrishna and Linda D. Cardozo},
  journal={International Urogynecology Journal},
  year={2012},
  volume={24},
  pages={537-543}
}
Overactive bladder (OAB) syndrome has a significant deleterious impact on quality of life. After conservative therapy and bladder retaining, antimuscarinic drugs remain the mainstay of OAB management. Oral therapy is associated with frequent side effects, leading to the development of alternative agents and formulations or the use of novel routes of drug administration, such as the vaginal route. The vagina is often ideal for drug delivery because it allows the use of lower doses, maintains… 
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TLDR
A range of drug delivery platforms suitable for intravaginal administration are discussed in this review, including hydrogels, vaginal tablets, pessaries/suppositories, particulate systems, and intravagsinal rings.
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TLDR
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TLDR
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TLDR
There were small significant reduction in systolic blood pressure, pulse rate, and forced expiratory volume in one second after vaginal administration but these did not cause any symptomatic side effects.
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TLDR
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