The vacuous chewing movement (VCM) model of tardive dyskinesia revisited: is there a relationship to dopamine D(2) receptor occupancy?

@article{Turrone2002TheVC,
  title={The vacuous chewing movement (VCM) model of tardive dyskinesia revisited: is there a relationship to dopamine D(2) receptor occupancy?},
  author={Peter Turrone and Gary J. Remington and Jos{\'e} N. Nobrega},
  journal={Neuroscience and biobehavioral reviews},
  year={2002},
  volume={26 3},
  pages={361-80}
}
Tardive dyskinesia (TD) is a late side effect of long-term antipsychotic use in humans, and the vacuous chewing movement (VCM) model has been used routinely to study this movement disorder in rats. Recent receptor occupancy studies in humans and rats have found that antipsychotics given in doses which lead to moderate levels of D(2) receptor blockade can achieve optimal clinical response while minimizing the emergence of acute motor side effects. This suggests that clinicians may have been… CONTINUE READING

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