The vacuolar transporter chaperone (VTC) complex is required for microautophagy.

  title={The vacuolar transporter chaperone (VTC) complex is required for microautophagy.},
  author={Andreas Uttenweiler and Heinz J. Schwarz and Heinz Neumann and Andreas Mayer},
  journal={Molecular biology of the cell},
  volume={18 1},
Microautophagy involves direct invagination and fission of the vacuolar/lysosomal membrane under nutrient limitation. This occurs by an autophagic tube, a specialized vacuolar membrane invagination that pinches off vesicles into the vacuolar lumen. In this study we have identified the VTC (vacuolar transporter chaperone) complex as required for microautophagy. The VTC complex is present on the ER and vacuoles and at the cell periphery. On induction of autophagy by nutrient limitation the VTC… CONTINUE READING


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Autophagic tubes: vacuolar invaginations involved in lateral membrane sorting and inverse vesicle budding

  • O. Muller, T. Sattler, M. Flotenmeyer, H. Schwarz, H. Plattner, A. Mayer
  • J. Cell Biol
  • 2000
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