The vacuolar (H+)-ATPases — nature's most versatile proton pumps

@article{Nishi2002TheV,
  title={The vacuolar (H+)-ATPases — nature's most versatile proton pumps},
  author={Tsuyoshi Nishi and Michael Forgac},
  journal={Nature Reviews Molecular Cell Biology},
  year={2002},
  volume={3},
  pages={94-103}
}
  • T. Nishi, M. Forgac
  • Published 1 February 2002
  • Biology
  • Nature Reviews Molecular Cell Biology
The pH of intracellular compartments in eukaryotic cells is a carefully controlled parameter that affects many cellular processes, including intracellular membrane transport, prohormone processing and transport of neurotransmitters, as well as the entry of many viruses into cells. The transporters responsible for controlling this crucial parameter in many intracellular compartments are the vacuolar (H+)-ATPases (V-ATPases). Recent advances in our understanding of the structure and regulation of… 
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