The vacuolar (H+)-ATPase: subunit arrangement and in vivo regulation

@article{Qi2007TheV,
  title={The vacuolar (H+)-ATPase: subunit arrangement and in vivo regulation},
  author={Jie Qi and Yanru Wang and Michael Forgac},
  journal={Journal of Bioenergetics and Biomembranes},
  year={2007},
  volume={39},
  pages={423-426}
}
The V-ATPases are responsible for acidification of intracellular compartments and proton transport across the plasma membrane. They play an important role in both normal processes, such as membrane traffic, protein degradation, urinary acidification, and bone resorption, as well as various disease processes, such as viral infection, toxin killing, osteoporosis, and tumor metastasis. V-ATPases contain a peripheral domain (V1) that carries out ATP hydrolysis and an integral domain (V0… 
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References

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TLDR
The V-type H+ ATPase is an ATP-driven enzyme that transforms the energy of ATP hydrolysis to electrochemical potential differences of protons across diverse biological membranes via the primary active transport of H+.
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TLDR
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TLDR
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TLDR
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TLDR
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