The v-sis Protein Retains Biological Activity as a Type II Membrane Protein When Anchored by Various Signal-Anchor Domains, Including the Hydrophobic Domain of the Bovine Papilloma Virus E50ncoprotein

Abstract

Membrane-anchored forms of the v-sis oncoprotein have been previously described which are oriented as type I transmembrane proteins and which efficiently induce autocrine transformation. Several examples of naturally occurring membrane-anchored growth factors have been identified, but all exhibit a type I orientation. In this work, we wished to construct… (More)

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