The utrophin actin-binding domain binds F-actin in two different modes

@article{Galkin2002TheUA,
  title={The utrophin actin-binding domain binds F-actin in two different modes},
  author={Vitold E Galkin and Albina Orlova and M S Vanloock and Inna N. Rybakova and James M. Ervasti and Edward H. Egelman},
  journal={The Journal of Cell Biology},
  year={2002},
  volume={157},
  pages={243 - 251}
}
Utrophin, like its homologue dystrophin, forms a link between the actin cytoskeleton and the extracellular matrix. We have used a new method of image analysis to reconstruct actin filaments decorated with the actin-binding domain of utrophin, which contains two calponin homology domains. We find two different modes of binding, with either one or two calponin-homology (CH) domains bound per actin subunit, and these modes are also distinguishable by their very different effects on F-actin… CONTINUE READING
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