The utility of next-generation sequencing in diagnosis and monitoring of acute myeloid leukemia and myelodysplastic syndromes.

@article{Duncavage2015TheUO,
  title={The utility of next-generation sequencing in diagnosis and monitoring of acute myeloid leukemia and myelodysplastic syndromes.},
  author={Eric J. Duncavage and Bevan Tandon},
  journal={International journal of laboratory hematology},
  year={2015},
  volume={37 Suppl 1},
  pages={115-21}
}
Myeloid malignancies including acute myeloid leukemia (AML) and myelodysplastic syndromes (MDS) are a heterogeneous group of disorders that share a common biology and are a major source of morbidity and mortality. In the last several years, studies using next-generation sequencing (NGS) have identified a core set of recurrently mutated myeloid malignancy genes in the majority of patients with AML and MDS, including those with normal cytogenetics. DNA-level mutations in several of these genes… CONTINUE READING
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Land - scape of genetic lesions in 944 patients with myelodysplastic syndromes

  • E Papaemmanuil, M Cazzola, +45 authors PJ Campbell
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  • 2014

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