The utility of fractional exhaled nitric oxide suppression in the identification of nonadherence in difficult asthma.

@article{McNicholl2012TheUO,
  title={The utility of fractional exhaled nitric oxide suppression in the identification of nonadherence in difficult asthma.},
  author={Diarmuid M. McNicholl and Michael Stevenson and Lorcan P. A. McGarvey and Liam G Heaney},
  journal={American journal of respiratory and critical care medicine},
  year={2012},
  volume={186 11},
  pages={1102-8}
}
RATIONALE Nonadherence to inhaled corticosteroid therapy (ICS) is a major contributor to poor control in difficult asthma, yet it is challenging to ascertain. OBJECTIVES Identify a test for nonadherence using fractional exhaled nitric oxide (Fe(NO)) suppression after directly observed inhaled corticosteroid (DOICS) treatment. METHODS Difficult asthma patients with an elevated Fe(NO) (>45 ppb) were recruited as adherent (ICS prescription filling >80%) or nonadherent (filling <50%). They… CONTINUE READING