The utility and limitations of neurosphere assay, CD133 immunophenotyping and side population assay in glioma stem cell research.

@article{Wan2010TheUA,
  title={The utility and limitations of neurosphere assay, CD133 immunophenotyping and side population assay in glioma stem cell research.},
  author={Feng Wan and Suojun Zhang and Ruifan Xie and Baocheng Gao and Benito Campos and Christel C. Herold-Mende and Ting Lei},
  journal={Brain pathology},
  year={2010},
  volume={20 5},
  pages={877-89}
}
The newly proposed glioma stem cell (GSC) hypothesis may re-model the way we diagnose and treat the tumor, which highlights the need for a complete knowledge on the genetic and epigenetic "blueprints" of GSCs. To identify the true "stemness" signatures, pure GSC populations are primarily needed. Reliable in vitro methods enriching for GSCs and thereby identifying the key stem-like characteristics constitute the preliminary step forward. We discuss in this review the current widely used methods… CONTINUE READING
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