The usefulness of the combined growth hormone (GH)-releasing hormone and arginine stimulation test in the diagnosis of radiation-induced GH deficiency is dependent on the post-irradiation time interval.

@article{Darzy2003TheUO,
  title={The usefulness of the combined growth hormone (GH)-releasing hormone and arginine stimulation test in the diagnosis of radiation-induced GH deficiency is dependent on the post-irradiation time interval.},
  author={Ken H. Darzy and G Aimaretti and Gilbert Wieringa and H. R. Gattamaneni and Ezio Ghigo and Stephen M. Shalet},
  journal={The Journal of clinical endocrinology and metabolism},
  year={2003},
  volume={88 1},
  pages={95-102}
}
The diagnostic usefulness of the insulin tolerance test (ITT) in patients with radiation-induced GH deficiency (GHD) is well established, whereas that of the combined GHRH plus arginine stimulation test (AST) is unproven. Both tests were undertaken in 49 adult survivors (aged 16-53.7 yr), who were previously irradiated for non-pituitary brain tumors or leukemia, and 33 age-, gender-, and BMI-matched controls. The aims of the study were to examine the impact of the time interval after… CONTINUE READING