The usefulness of patch testing on the previously most severely affected site in a cutaneous adverse drug reaction to tetrazepam

  title={The usefulness of patch testing on the previously most severely affected site in a cutaneous adverse drug reaction to tetrazepam},
  author={Annick Barbaud and Philippe Tr{\'e}chot and S. Reichert-P{\'e}n{\'e}trat and Florence Granel and Jean Luc Schmutz},
  journal={Contact Dermatitis},
Influye la altura de la vivienda en la sensibilización a los pólenes
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Delayed‐type drug hypersensitivity caused by paracetamol in a 2‐year‐old boy, confirmed by a positive patch test reaction and oral provocation
Delayed-type drug hypersensitivity caused by paracetamol in a 2-year-old boy, confirmed by a positive patch test reaction and oral provocation Liesbeth Gilissen1 , Sarien Mertens1, An Goossens1 ,
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On the clinical evidence leading to tetrazepam withdrawal
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Patch Testing for Drugs
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Cutaneous adverse drug reactions (CADRs), defined as skin eruptions induced by drugs used in adequate doses and in the correct indications, present under different clinical patterns, and the


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Drugs can induce various cutaneous adverse reactions with a wide range of clinical manifestations but some reactions are thought to be immunoallergological, and immediate immunoglobulin E-mediated drug reactions may be involved in urticaria.
The use of skin testing in the investigation of cutaneous adverse drug reactions
The value of careful sequential drug skin testing in establishing the cause of cutaneous ADR is supported, as a significantly higher number of positive patch tests was observed in maculopapular rashes than in urticarial reactions.
Delayed cell‐mediated hypersensitivity to tetrazepam
A 59-year-old man, with degenerative arthritis, was treated daily with 1 capsule of Myolastan® (50 mg tetrazepam) and developed an itchy maculopapular rash and tightness of the chest, without wheezing.
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In February 1989, a 63-year-old man, with lumbar intervertebral degenerative arthritis, presented with maculopapular to purpuric lesions on the legs, which had appeared some days after the
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Case no. 1. A 71-year-old man, with cervical arthralgia for 2 years, was successfully treated with 50 mg ofMyolastan® (tetrazepam) daily, taken at night, and 16 mg of Fidium® (betahistidine
Fixed drug eruption: an immunohistochemical investigation of the acute and healing phase
T suppressor/cytotoxic cells seemed to play a major role in initiating the flare‐up reaction and preserving the cutaneous memory function of the fixed drug eruption.
Topical provocation of fixed drug eruption
The present study suggests that topical provocation is useful with several drugs causing FDE, and the sensitivity of the open topical testing can be increased in certain cases by using a vehicle which increases penetration of the drug.