The usefulness of holotranscobalamin in predicting vitamin B12 status in different clinical settings.

@article{Herrmann2005TheUO,
  title={The usefulness of holotranscobalamin in predicting vitamin B12 status in different clinical settings.},
  author={Wolfgang Herrmann and Hussain M Awwad and Heike Schorr and Juergen Geisel},
  journal={Current drug metabolism},
  year={2005},
  volume={6 1},
  pages={47-53}
}
Serum concentrations of homocysteine (Hcy) and methylmalonic acid (MMA) become increased in B12-deficient subjects and are therefore, considered specific markers of B12 deficiency. Serum level of holotranscobalamin (holoTC) becomes decreased before the development of the metabolic dysfunction. We investigated the usefulness of holoTC in diagnosing B12 deficiency in some clinical settings. We measured serum concentrations of holoTC, MMA, Hcy and total B12 in omnivores, vegetarians, elderly… CONTINUE READING
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