The use of vitamin E for the prevention of chemotherapy-induced peripheral neuropathy: results of a randomized phase III clinical trial

@article{Kottschade2010TheUO,
  title={The use of vitamin E for the prevention of chemotherapy-induced peripheral neuropathy: results of a randomized phase III clinical trial},
  author={Lisa A. Kottschade and Jeff A. Sloan and Miroslaw A. Mazurczak and David B F Johnson and Bronagh P. Murphy and Kendrith M. Rowland and Dennison Alvord Smith and Alan Berg and Philip J. Stella and Charles L Loprinzi},
  journal={Supportive Care in Cancer},
  year={2010},
  volume={19},
  pages={1769-1777}
}
Chemotherapy-induced peripheral neuropathy (CIPN) continues to be a substantial problem for many cancer patients. Pursuant to promising appearing pilot data, the current study evaluated the use of vitamin E for the prevention of CIPN. A phase III, randomized, double-blind, placebo-controlled study was conducted in patients undergoing therapy with neurotoxic chemotherapy, utilizing twice daily dosing of vitamin E (400 mg)/placebo. The primary endpoint was the incidence of grade 2+ sensory… CONTINUE READING
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