The use of vasopressin receptor antagonists in hyponatremia.

  title={The use of vasopressin receptor antagonists in hyponatremia.},
  author={Elwaleed A M Elhassan and Robert Schrier},
  journal={Expert opinion on investigational drugs},
  volume={20 3},
INTRODUCTION Considerable data have recently characterized hyponatremia as fairly common in the intensive care and general hospital settings. Moreover, mounting evidence suggests the association of mild degrees of hyponatremia with untoward neurocognitive and musculoskeletal outcomes. A key development in our ability to treat hyponatremia was the introduction and approval of aquaretics (vaptans). These vasopressin receptor antagonists work by increasing electrolyte-free water excretion and thus… CONTINUE READING