• Corpus ID: 27400478

The use of urea and its derivatives in the cosmetics industry

@inproceedings{Kapuciska2014TheUO,
  title={The use of urea and its derivatives in the cosmetics industry},
  author={Alicja Kapuścińska and Izabela Nowak},
  year={2014}
}
Urea as chemical substance Urea is a natural chemical compound, produced in human organism as a metabolite of proteins and other nitrogencontaining compounds [4]. It is released in urine and sweat in amount 20–30 mg per day. Urea is a carbonic acid diamide (carbamide, CAS number: 57–13–6). It occurs in the form of odourless, colourless crystals whose melting point is 133oC, highly soluble in water and ethanol. It was for the first time synthesised in 1828 by a German chemist Friedrich Wöhler [4… 

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References

SHOWING 1-10 OF 25 REFERENCES

Contact allergy to diazolidinyl urea (Germall II®)

4 cases of contact allergy to diazolidinyl urea (Germall II®) in a “hypoallergenic” brand of cosmetics are described, 2 patients sensitized by these cosmetics were not allergic to formaldehyde. 2

Analysis of electrical property changes of skin by oil-in-water emulsion components

TLDR
This study investigates the moisturizing effect of oil‐in‐water (O/W) emulsion components in skincare products to understand each use to make an effective moisturizing products.

[Topically applied arginine hydrochloride. Effect on urea content of stratum corneum and skin hydration in atopic eczema and skin aging].

TLDR
The urea deficit in the stratum corneum in atopic dermatitis and elderly skin was corrected not by applying the moisturizer urea itself but instead by using arginine - its precursor in the Krebs-Henseleit urea cycle.

Skin hydration: a review on its molecular mechanisms

TLDR
The discovery of the existence of the water‐transporting protein aquaporin‐3 in the viable epidermis and the presence of tight junction structures at the junction between the stratum granulosum and SC have brought new insights into the mechanisms of skin water distribution and barrier function.

Urea-containing moisturizers influence barrier properties of normal skin

  • M. Lóden
  • Chemistry, Medicine
    Archives of Dermatological Research
  • 2006
TLDR
Urea was found to decrease the skin susceptibility to SLS after only three applications and the lower degree of SLS-induced irritation in the skin treated previously with urea-containing moisturizers may be of clinical relevance in reducing contact dermatitis from irritant stimuli.

Cream or foam in pedal skin care: towards the ideal vehicle for urea used against dry skin

TLDR
It looks as if cream vehicles would still be vehicles of choice in general, when it comes to the formulation of skin care preparations for not only dry skin but also in the context of pedal skin care.

A double-blind comparison of two creams containing urea as the active ingredient. Assessment of efficacy and side-effects by non-invasive techniques and a clinical scoring scheme.

  • J. Serup
  • Medicine
    Acta dermato-venereologica. Supplementum
  • 1992
TLDR
The 3% and 10% urea creams were both found efficient, resulting in improvement of hydration and reduction of scaling, and clinical improvement of dryness, and both were non-toxic.

Aquaporin homologues in plants and mammals transport ammonia

Hydrating effects of moisturizer active compounds incorporated into hydrogels: in vivo assessment and comparison between devices

TLDR
The measurement of stratum corneum hydration is widely employed to verify the moisture effect of topical products and, when dehydrated, it becomes rough and flaky.

Improvement of skin barrier function during treatment of atopic dermatitis.