The use of ultrasonication to aid recellularization of acellular natural tissue scaffolds for use in anterior cruciate ligament reconstruction.

@article{Ingram2007TheUO,
  title={The use of ultrasonication to aid recellularization of acellular natural tissue scaffolds for use in anterior cruciate ligament reconstruction.},
  author={Joanne Helen Ingram and Sotirios Korossis and Graeme I Howling and John Berton Fisher and Eileen Ingham},
  journal={Tissue engineering},
  year={2007},
  volume={13 7},
  pages={1561-72}
}
Tissue engineering offers a promising solution to the replacement of anterior cruciate ligament. A decellularized porcine patella tendon scaffold was produced by immersing whole tissues sequentially in hypotonic buffer, 0.1% (w/v) sodium dodecyl sulfate (SDS) in hypotonic buffer, and nuclease solution prior to sterilization with 0.1% (w/v) peracetic acid. Initial studies revealed that primary human tenocytes would attach to, but failed to penetrate into, the decellularized scaffold. A novel use… CONTINUE READING
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