The use of tryptophan depletion to evaluate central serotonin function in depression and other neuropsychiatric disorders.

@article{Salomon1993TheUO,
  title={The use of tryptophan depletion to evaluate central serotonin function in depression and other neuropsychiatric disorders.},
  author={Ronald M. Salomon and Helen L Miller and Pedro L. Delgado and Dennis S. Charney},
  journal={International clinical psychopharmacology},
  year={1993},
  volume={8 Suppl 2},
  pages={41-6}
}
The results from these and other studies provide an opportunity to critically re-examine the role of brain monoamine function in the pathophysiology of depression and the mechanism of action of antidepressant drugs. The following observations are most salient: 1. Tryptophan depletion, which reduces brain serotonin function, reverses the therapeutic effects of specific serotonin reuptake inhibitors (SSRIs) but not drugs which potently inhibit noradrenaline reuptake. In contrast, depletion of… CONTINUE READING