The use of trimeric isoleucine-zipper fusion proteins to study surface-receptor-ligand interactions in natural killer cells.

@article{Stark2005TheUO,
  title={The use of trimeric isoleucine-zipper fusion proteins to study surface-receptor-ligand interactions in natural killer cells.},
  author={Sebastian Stark and Ruediger Marcus Flaig and Mina Sandusky and Carsten Watzl},
  journal={Journal of immunological methods},
  year={2005},
  volume={296 1-2},
  pages={
          149-58
        }
}
The ligands for several activating natural killer (NK) cell receptors have not been identified to date. Soluble receptor fusion proteins can be used to stain target cells for the presence of these unidentified ligands. Here, we describe the generation and use of soluble type I NK cell receptor isoleucine-zipper (ILZ) fusion proteins of the immunoglobulin (Ig) superfamily. ILZ-fusion proteins are easy to produce and purify. They form trimeric complexes in solution and display a higher binding… CONTINUE READING

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