The use of transgenic mouse models of amyotrophic lateral sclerosis in preclinical drug studies.

@article{Gurney1997TheUO,
  title={The use of transgenic mouse models of amyotrophic lateral sclerosis in preclinical drug studies.},
  author={Mark E Gurney},
  journal={Journal of the neurological sciences},
  year={1997},
  volume={152 Suppl 1},
  pages={S67-73}
}
  • Mark E Gurney
  • Published 1997 in Journal of the neurological sciences
The discovery of mutations in the human SOD1 gene encoding Cu,Zn superoxide dismutase (Cu,Zn SOD) in patients with familial amyotrophic lateral sclerosis (ALS) has made possible the development of etiological models of the disease. Expression of mutant SOD1 genes in transgenic mice causes a progressive paralytic disease whose general features resemble ALS in humans. We have used the transgenic model to explore etiological mechanisms and to screen potential therapeutics. Our results and those of… CONTINUE READING

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