The use of thyroid function tests in the diagnosis of hypopituitarism: definition and evaluation of the TSH Index

@article{Jostel2009TheUO,
  title={The use of thyroid function tests in the diagnosis of hypopituitarism: definition and evaluation of the TSH Index},
  author={A. Jostel and W. Ryder and S. Shalet},
  journal={Clinical Endocrinology},
  year={2009},
  volume={71}
}
Background  TSH secretion in hypopituitary patients may be decreased due to TSH deficiency but it also remains under feedback inhibition by free thyroxine (fT4). We propose a TSH index (TSHI), as ‘fT4‐adjusted TSH’, that corrects for any physiological TSH suppression, to provide a true estimate of pituitary thyrotroph function and any pathological pituitary suppression. 

Paper Mentions

Observational Clinical Trial
The NOMOTHETICOS study is a unicentric cross-sectional study for a quantitative analysis of feedback-inhibition in the thyrotropic homeostatic control. Structural parameters are… Expand
ConditionsHyperthyroidism, Hypothyroidism
Central hypothyroidism in adults: better understanding for better care
Central hypothyroidism in children.
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