The use of the writhing test in mice for screening different types of analgesics.

@article{Gyires1984TheUO,
  title={The use of the writhing test in mice for screening different types of analgesics.},
  author={Kl{\'a}ra Gyires and Z Torma},
  journal={Archives internationales de pharmacodynamie et de therapie},
  year={1984},
  volume={267 1},
  pages={131-40}
}
The prostaglandin synthesis inhibitors studied were highly potent analgesics against ATP and ACh-induced writhing, but slightly effective or ineffective against MgSO4-induced pain. Morphine also proved to be more effective against ATP and ACh than against MgSO4-induced writhing. ATP and ACh-induced writhing syndrome could be inhibited by the prostaglandin receptor antagonist- Sc-19220. However, Sc-19220 failed to inhibit writhing elicited by MgSO4. The concentration of malondialdehyde was… CONTINUE READING