The use of the new ReFacto AF Laboratory Standard allows reliable measurement of FVIII:C levels in ReFacto AF mock plasma samples by a one-stage clotting assay.

@article{Pouplard2011TheUO,
  title={The use of the new ReFacto AF Laboratory Standard allows reliable measurement of FVIII:C levels in ReFacto AF mock plasma samples by a one-stage clotting assay.},
  author={Claire Pouplard and Claudine Caron and M F Aillaud and Catherine Ternisien and C{\'e}line Desconclois and Arnaud Dubanchet and Fr{\'e}d{\'e}ric Sobas},
  journal={Haemophilia : the official journal of the World Federation of Hemophilia},
  year={2011},
  volume={17 5},
  pages={
          e958-62
        }
}
Factor VIII coagulant (FVIII:C) levels measured in patients receiving ReFacto® (B-domain-deleted recombinant FVIII) using chromogenic substrate assay (CSA) and one-stage clotting assay (OSA) have frequently shown discrepancies, and the use of the ReFacto Laboratory Standard (RLS) has therefore been recommended to minimize these differences. The potency of ReFacto AF®, the albumin-free successor of ReFacto®, is determined using CSA for the titration of vials, and a new standard (RLS-AF) was… CONTINUE READING

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