Corpus ID: 31548377

The use of the exploratory IND in the evaluation and development of 18F-PET radiopharmaceuticals for amyloid imaging in the brain: a review of one company's experience.

@article{Carpenter2009TheUO,
  title={The use of the exploratory IND in the evaluation and development of 18F-PET radiopharmaceuticals for amyloid imaging in the brain: a review of one company's experience.},
  author={Alan P. Carpenter and Michael Pontecorvo and Franz F. Hefti and Daniel M. Skovronsky},
  journal={The quarterly journal of nuclear medicine and molecular imaging : official publication of the Italian Association of Nuclear Medicine (AIMN) [and] the International Association of Radiopharmacology (IAR), [and] Section of the Society of...},
  year={2009},
  volume={53 4},
  pages={
          387-93
        }
}
  • Alan P. Carpenter, Michael Pontecorvo, +1 author Daniel M. Skovronsky
  • Published in
    The quarterly journal of…
    2009
  • Medicine
  • AIM AND METHODS The regulatory mechanism of exploratory INDs established in 2006 by the US Food and Drug Administration (FDA) is useful for the evaluation of tracer dose radiopharmaceutical agents, and especially valuable for development of amyloid imaging agents because of the absence of appropriate animal models. The authors employed exploratory INDs to study four related novel 18F-labeled positron emission tomography (PET) amyloid imaging agents, 18F-AV-19, 18F-AV-45, 18F-AV-138 and 18F-AV… CONTINUE READING

    Create an AI-powered research feed to stay up to date with new papers like this posted to ArXiv

    Topics from this paper.

    Citations

    Publications citing this paper.
    SHOWING 1-10 OF 24 CITATIONS

    Amyloid plaque imaging from IMPY/SPECT to AV-45/PET.

    VIEW 12 EXCERPTS
    CITES BACKGROUND
    HIGHLY INFLUENCED

    Bringing New PET Drugs to Clinical Practice - A Regulatory Perspective

    VIEW 3 EXCERPTS
    CITES BACKGROUND
    HIGHLY INFLUENCED

    Perspective on How the FDA Should Review Diagnostic Radiopharmaceuticals.

    VIEW 1 EXCERPT
    CITES BACKGROUND