The use of the SeDeM Diagram expert system to determine the suitability of diluents-disintegrants for direct compression and their use in formulation of ODT.

@article{AguilarDaz2009TheUO,
  title={The use of the SeDeM Diagram expert system to determine the suitability of diluents-disintegrants for direct compression and their use in formulation of ODT.},
  author={Johnny Edward Aguilar-D{\'i}az and Encarnaci{\'o}n Garc{\'i}a-Montoya and Pilar P{\'e}rez-Lozano and Jos{\'e} Mar{\'i}a Su{\~n}{\'e}-Negre and Montserrat Mi{\~n}arro and Jos{\'e} Ram{\'o}n Tic{\'o}},
  journal={European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V},
  year={2009},
  volume={73 3},
  pages={414-23}
}
The new SeDeM Diagram expert system was used to analyze the suitability of 43 excipients for direct compression with disintegrant properties from eight chemical families. The SeDeM Diagram expert system is a new method for use in tablet preformulation and formulation studies. It provides the profile of a substance in powder form in terms of its suitability for direct compression. This study, which was based on the current concept of "Quality by Design ICH Q8", evaluated the pharmacotechnical… CONTINUE READING

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