The use of sleep measures to compare a new 5HT1A agonist with buspirone in humans.

@article{Wilson2005TheUO,
  title={The use of sleep measures to compare a new 5HT1A agonist with buspirone in humans.},
  author={Sue J. Wilson and Jayne E. Bailey and Ann S. Rich and Jon Nash and Mariona Adrover and Alan Tournoux and David J. Nutt},
  journal={Journal of psychopharmacology},
  year={2005},
  volume={19 6},
  pages={
          609-13
        }
}
The partial agonist buspirone has a REM (rapid eye movement) suppressing effect on human sleep probably via a 5HT(1A) receptor in the pontine area. Eptapirone is a new 5HT(1A) agonist with a greater intrinsic effect than buspirone. The objective of this study was to examine the effects of eptapirone on sleep architecture, particularly REM sleep, in normal volunteers and compare it with buspirone and placebo. This was a randomized, double-blind placebo-controlled four-way crossover study in 12… CONTINUE READING

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