The use of scintigraphy to demonstrate the rapid esophageal transit of the oval film-coated placebo risedronate tablet compared to a round uncoated placebo tablet when administered with minimal volumes of water.

@article{Perkins2001TheUO,
  title={The use of scintigraphy to demonstrate the rapid esophageal transit of the oval film-coated placebo risedronate tablet compared to a round uncoated placebo tablet when administered with minimal volumes of water.},
  author={Alan C. Perkins and Clive G. Wilson and Malcolm E. Frier and Patricia E Blackshaw and Richard J Dansereau and Rebecca M. Vincent and Dietrich Wenderoth and Shannon Hathaway and Zhengqing Li and Robin C Spiller},
  journal={International journal of pharmaceutics},
  year={2001},
  volume={222 2},
  pages={295-303}
}
As our population ages, and the consumption of pharmaceutical products rises, the incidence of solid oral dosage forms lodging in the esophagus is likely to increase and may be formulation dependent. The aim of this study was to compare the esophageal transit of the commercial film-coated risedronate tablet and a round uncoated tablet resembling the alendronate 10 mg tablet which is reported to cause esophagitis if ingested with little to no water. Water volumes of 30 ml and 50 ml were selected… CONTINUE READING

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This study demonstrates that tablet size , shape and coating are pharmaceutical parameters which can be controlled to minimize esophageal contact of a dosage form with esophageal tissue .
This study demonstrates that tablet size , shape and coating are pharmaceutical parameters which can be controlled to minimize esophageal contact of a dosage form with esophageal tissue .
This study demonstrates that tablet size , shape and coating are pharmaceutical parameters which can be controlled to minimize esophageal contact of a dosage form with esophageal tissue .
The aim of this study was to compare the esophageal transit of the commercial film - coated risedronate tablet and a round uncoated tablet resembling the alendronate 10 mg tablet which is reported to cause esophagitis if ingested with little to no water
The aim of this study was to compare the esophageal transit of the commercial film - coated risedronate tablet and a round uncoated tablet resembling the alendronate 10 mg tablet which is reported to cause esophagitis if ingested with little to no water
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