The use of restriction endonucleases in the prenatal diagnosis of hemoglobinopathies.

  • David H Gutmann
  • Published 1982 in The American journal of medical technology


Enzymes which fragment DNA at specific sites have been used to prenatally detect sickle cell anemia, alpha-thalassemia, and beta-thalassemia from amniotic fluid aspirates. Within the last few years, the use of combined restriction endonuclease systems (EcoRI and HindIII) for the antenatal detection of sickle cell anemia was found to provide an exact… (More)


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