The use of random effects models to allow for clustering in individually randomized trials.

@article{Lee2005TheUO,
  title={The use of random effects models to allow for clustering in individually randomized trials.},
  author={Katherine J. Lee and Simon Giles Thompson},
  journal={Clinical trials},
  year={2005},
  volume={2 2},
  pages={163-73}
}
BACKGROUND We describe different forms of clustering that may occur in individually randomized trials, where the observed outcomes for different individuals cannot be regarded as independent. We propose random effects models to allow for such clustering, across a range of contexts and trial designs, and investigate their effect on estimation and interpretation of the treatment effect. METHODS We apply our proposed models to two individually randomized trials with potential for clustering, a… CONTINUE READING

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