The use of radiolabeled compounds for ADME studies in discovery and exploratory development.

@article{Marathe2004TheUO,
  title={The use of radiolabeled compounds for ADME studies in discovery and exploratory development.},
  author={Punit H. Marathe and Wen Chyi Shyu and W Griffith Humphreys},
  journal={Current pharmaceutical design},
  year={2004},
  volume={10 24},
  pages={
          2991-3008
        }
}
Radiolabeled compounds are excellent investigative tools and widely used to carry out ADME studies during drug discovery and development stages. The most commonly used radioisotopes are 14C and 3H. 3H materials are generally easier to synthesize than 14C materials. Therefore, a variety of probes and substrates used in in vitro assays are labeled with 3H… CONTINUE READING