The use of quantitative real-time reverse transcriptase PCR for 5' and 3' portions of ALK transcripts to detect ALK rearrangements in lung cancers.

@article{Wang2012TheUO,
  title={The use of quantitative real-time reverse transcriptase PCR for 5' and 3' portions of ALK transcripts to detect ALK rearrangements in lung cancers.},
  author={Rui Wang and Yunjian Pan and Chenguang Li and Haichuan Hu and Yang Zhang and Hang Li and Xiaoyang Luo and Jie Zhang and Zhaoyuan Fang and Yuan Li and Lei Shen and Hongbin Ji and David Garfield and Yihua Sun and Haiquan Chen},
  journal={Clinical cancer research : an official journal of the American Association for Cancer Research},
  year={2012},
  volume={18 17},
  pages={4725-32}
}
PURPOSE Approximately 3% to 7% of non-small cell lung cancers (NSCLC) harbor an ALK fusion gene, thus defining a tumor group that may be responsive to targeted therapy. The breakpoint in ALK consistently occurs at exon 20 and EML4 or other fusion partners, thus driving a strong expression of ALK kinase domain and resulting in an unbalanced expression in 5' and 3' portions of ALK transcripts. We have developed a rapid and accurate method by simultaneously detecting the expression in 5' and 3… CONTINUE READING
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