The use of prognostic factors in clinical trials.

@article{Sather1986TheUO,
  title={The use of prognostic factors in clinical trials.},
  author={Harland N. Sather},
  journal={Cancer},
  year={1986},
  volume={58 2 Suppl},
  pages={461-7}
}
Numerous examples exist of prognostic factors that have been conclusively established and that can segregate the target patient population into subgroups with vastly different outcomes. At the same time, we can expect, in the majority of trials being conducted, that if a new treatment turns out to be successful, it generally results in only a modest improvement in patient outcome. This has contributed to a major emphasis on the identification and use of prognostic factors in clinical trials… CONTINUE READING

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