The use of plasma desorption time-of-flight mass spectrometry to screen for products of prohormone processing in crude tissue extracts.

@article{Andrews1988TheUO,
  title={The use of plasma desorption time-of-flight mass spectrometry to screen for products of prohormone processing in crude tissue extracts.},
  author={P. Andrews and M. Alai and R. Cotter},
  journal={Analytical biochemistry},
  year={1988},
  volume={174 1},
  pages={
          23-31
        }
}
  • P. Andrews, M. Alai, R. Cotter
  • Published 1988
  • Chemistry, Medicine
  • Analytical biochemistry
    • Californium-252 plasma desorption mass spectrometry (252Cf PDMS) of a crude, desalted, extract of piscine endocrine pancreas provided mass information for the major biologically active peptide hormones present in this tissue. An extraction procedure compatible with 252Cf PDMS analysis was developed. In extracts of catfish pancreas, strong molecular ions were identified in the positive mode for somatostatin-14 (1638 amu), O-glycosylated somatostatin-22 (2944 amu), glucagon (3512 amu), glucagon… CONTINUE READING
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